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USMLE Step 1

2 guides for this exam — how to prepare, what to practise, and how to know it has gone in.

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A practice question

Choose an answer and it is marked, with the explanation. From USMLE Step 1 Practice Questions: 10 Worked Items.

Question 11 mark

A 32-year-old woman has amenorrhea, galactorrhea, and decreased libido. MRI shows a 9-mm pituitary microadenoma. Which medication most directly reduces the hormone driving her symptoms?

Cabergoline is a dopamine D2-receptor agonist. Dopamine released by the hypothalamus tonically inhibits prolactin secretion from lactotrophs, so a dopamine agonist lowers prolactin and often shrinks a prolactinoma. Octreotide suppresses growth hormone and is the strongest distractor because it is also used for a pituitary adenoma, but it does not directly treat hyperprolactinemia.

A single-best-answer question tests the mechanism of prolactin suppression.
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